| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human MADCAM1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Immobilized Human MADCAM1, His Tag at 0.5 Mu g/ml (100 Mu l/Well) on the plate. Dose response curve for Anti-MADCAM1 Antibody, hFc Tag with the EC50 of 7.7ng/ml determined by ELISA. |
| Gene Symbol: |
MADCAM1 |
| Gene ID: |
8174 |
| Uniprot ID: |
MADCA_HUMAN |
| Immunogen Region: |
Gln19-Gln317 |
| Immunogen: |
Recombinant Human MADCAM1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln19-Gln317) of human MADCAM1 (Accession #NP_570116.2) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation. |
| Function | Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. |
| Protein Name | Mucosal Addressin Cell Adhesion Molecule 1Madcam-1Hmadcam-1 |
| Database Links | Reactome: R-HSA-198933 Q13477-1Reactome: R-HSA-216083 Q13477-1 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Mucosal Addressin Cell Adhesion Molecule 1 proteinMadcam-1 proteinHmadcam-1 proteinMADCAM1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
