Human MADCAM1 protein (Recombinant) (C-Fc) (STJP006796)

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STJP006796
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MADCAM1-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MADCAM1
Gene ID: 8174
Uniprot ID: MADCA_HUMAN
Immunogen Region: Met1-Leu318
Immunogen: Homo sapiens (Human)
Post Translational Modifications The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
Function Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Protein Name Mucosal Addressin Cell Adhesion Molecule 1
Madcam-1
Hmadcam-1
Database Links Reactome: R-HSA-198933 Q13477-1
Reactome: R-HSA-216083 Q13477-1
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Mucosal Addressin Cell Adhesion Molecule 1 protein
Madcam-1 protein
Hmadcam-1 protein
MADCAM1 protein

Information sourced from Uniprot.org

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