| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.061ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This LRP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
LRP1 |
| Gene ID: |
4035 |
| Uniprot ID: |
LRP1_HUMAN |
| Sample Type: |
serum, plasma or other biological fluids. |
| Tissue Specificity | Most abundant in liver, brain and lung. |
| Post Translational Modifications | Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1. |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. |
| Protein Name | Prolow-Density Lipoprotein Receptor-Related Protein 1Lrp-1Alpha-2-Macroglobulin ReceptorA2mrApolipoprotein E ReceptorApoerCd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda SubunitLrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda SubunitLrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular DomainLrpicd |
| Database Links | Reactome: R-HSA-2168880Reactome: R-HSA-975634 |
| Cellular Localisation | Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell MembraneSingle-Pass Type I Membrane ProteinMembraneCoated PitLow-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell MembranePeripheral Membrane ProteinExtracellular SideLow-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: CytoplasmNucleusAfter CleavageThe Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The NucleusGolgi OutpostCytoplasmCytoskeletonMicrotubule Organizing CenterLocalizes To The Postsynaptic Golgi Apparatus RegionAlso Named Golgi OutpostWhich Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation |
| Alternative ELISA Names | Prolow-Density Lipoprotein Receptor-Related Protein 1 ELISA kitLrp-1 ELISA kitAlpha-2-Macroglobulin Receptor ELISA kitA2mr ELISA kitApolipoprotein E Receptor ELISA kitApoer ELISA kitCd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit ELISA kitLrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit ELISA kitLrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain ELISA kitLrpicd ELISA kitLRP1 ELISA kitA2MR ELISA kitAPR ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
