• Human LNPEP (Leucyl/Cystinyl Aminopeptidase) Sandwich ELISA Kit (STJE0010374)

Human LNPEP (Leucyl/Cystinyl Aminopeptidase) Sandwich ELISA Kit (STJE0010374)

SKU:
STJE0010374

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.58ng/mL
Detection Limit: 1.56-100ng/mL
Short Description: This LNPEP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: LNPEP
Gene ID: 4012
Uniprot ID: LCAP_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.
Post Translational Modifications The pregnancy serum form is derived from the membrane-bound form by proteolytic processing. N-glycosylated.
Function Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Protein Name Leucyl-Cystinyl Aminopeptidase
Cystinyl Aminopeptidase
Insulin-Regulated Membrane Aminopeptidase
Insulin-Responsive Aminopeptidase
Irap
Oxytocinase
Otase
Placental Leucine Aminopeptidase
P-Lap Cleaved Into - Leucyl-Cystinyl Aminopeptidase - Pregnancy Serum Form
Database Links Reactome: R-HSA-1236977
Reactome: R-HSA-1445148
Reactome: R-HSA-983168
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
In Brain Only The Membrane-Bound Form Is Found
The Protein Resides In Intracellular Vesicles Together With Glut4 And Can Then Translocate To The Cell Surface In Response To Insulin And/Or Oxytocin
Localization May Be Determined By Dileucine Internalization Motifs
And/Or By Interaction With Tankyrases
Leucyl-Cystinyl Aminopeptidase
Pregnancy Serum Form: Secreted
During Pregnancy Serum Levels Are Low In The First Trimester
Rise Progressively During The Second And Third Trimester And Decrease Rapidly After Parturition
Alternative ELISA Names Leucyl-Cystinyl Aminopeptidase ELISA kit
Cystinyl Aminopeptidase ELISA kit
Insulin-Regulated Membrane Aminopeptidase ELISA kit
Insulin-Responsive Aminopeptidase ELISA kit
Irap ELISA kit
Oxytocinase ELISA kit
Otase ELISA kit
Placental Leucine Aminopeptidase ELISA kit
P-Lap Cleaved Into - Leucyl-Cystinyl Aminopeptidase - Pregnancy Serum Form ELISA kit
LNPEP ELISA kit
OTASE ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance