| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human LILRB4 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human ANGPTL7 with a linear range of 0.12-0.5 Mu g/mL.|2.Measured by its binding ability in a functional E |
| Gene Symbol: |
LILRB4 |
| Gene ID: |
11006 |
| Uniprot ID: |
LIRB4_HUMAN |
| Immunogen: |
Recombinant Human LILRB4/ILT-3/CD85k Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-Glu259) of human LILRB4/CD85k/ILT3 (Accession #NP_001265356.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
QAGPLPKPTLWAEPGSVISW GNSVTIWCQGTLEAREYRLD KEESPAPWDRQNPLEPKNKA RFSIPSMTEDYAGRYRCYYR SPVGWSQPSDPLELVMTGAY SKPTLSALPSPLVTSGKSVT LLCQSRSPMDTFLLIKERAA HPLLHLRSEHGAQQHQAEFP MSPVTSVHGGTYRCFSSHGF SHYLLSHPSDPLELIVSGSL EGPRPSPTRSVSTAAGPEDQ PLMPTGSVPHSGLRRHWE |
| Function | Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance. Receptor for FN1. Receptor for apolipoprotein APOE. Receptor for ALCAM/CD166. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production. This inhibition of monocyte activation occurs at least in part via binding to FN1. Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells. Induces up-regulation of CD86 on dendritic cells. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4B4Cd85 Antigen-Like Family Member KImmunoglobulin-Like Transcript 3Ilt-3Leukocyte Immunoglobulin-Like Receptor 5Lir-5Monocyte Inhibitory Receptor Hm18Cd Antigen Cd85k |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLigand Binding Leads To Internalization And Translocation To An Antigen-Processing Compartment |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 proteinB4 proteinCd85 Antigen-Like Family Member K proteinImmunoglobulin-Like Transcript 3 proteinIlt-3 proteinLeukocyte Immunoglobulin-Like Receptor 5 proteinLir-5 proteinMonocyte Inhibitory Receptor Hm18 proteinCd Antigen Cd85k proteinLILRB4 proteinILT3 proteinLIR5 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
