Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human LILRA4/CD85g-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Endotoxin: |
Less than 1EU per Mu g by the LAL method. |
Gene Symbol: |
LILRA4 |
Gene ID: |
23547 |
Uniprot ID: |
LIRA4_HUMAN |
Immunogen Region: |
Glu24-Asn446 |
Immunogen: |
Recombinant Human LILRA4/CD85g Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal.;It contains Glu24-Asn446. |
Function | Functions coreceptor to limit the innate immune responses to viral infections.signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. |
Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4Cd85 Antigen-Like Family Member GImmunoglobulin-Like Transcript 7Ilt-7Cd Antigen Cd85g |
Database Links | Reactome: R-HSA-198933 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4 proteinCd85 Antigen-Like Family Member G proteinImmunoglobulin-Like Transcript 7 proteinIlt-7 proteinCd Antigen Cd85g proteinLILRA4 proteinILT7 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance