| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.056ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This KNTC1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
KNTC1 |
| Gene ID: |
9735 |
| Uniprot ID: |
KNTC1_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | High expression in testis. |
| Post Translational Modifications | |
| Function | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. |
| Protein Name | Kinetochore-Associated Protein 1Rough Deal HomologHsrodRodHrod |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmNucleusChromosomeCentromereKinetochoreCytoskeletonSpindleDynamic Pattern Of Localization During The Cell CycleAt InterphaseUniformly Distributed Throughout The Cytoplasm And NucleusBy Prophase And Until Late Stages Of PrometaphaseA Fraction Of The Total Pool Is Concentrated At KinetochoresBy MetaphaseDetected At KinetochoresAlong Spindle Fibers And Most Prominently At The PolesBy Late Anaphase Until The End Of TelophaseNo Longer Detectable On Kinetochores Or Along Spindle FibersBut Still Present At The Spindle Poles |
| Alternative ELISA Names | Kinetochore-Associated Protein 1 ELISA kitRough Deal Homolog ELISA kitHsrod ELISA kitRod ELISA kitHrod ELISA kitKNTC1 ELISA kitKIAA0166 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
