• Human KLK8 (Kallikrein 8) Sandwich ELISA Kit Ready-To-Use (STJE0016590)

Human KLK8 (Kallikrein 8) Sandwich ELISA Kit Ready-To-Use (STJE0016590)

SKU:
STJE0016590

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.244ng/mL
Detection Limit: 0.781-50ng/mL
Short Description: This KLK8 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: KLK8
Gene ID: 11202
Uniprot ID: KLK8_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.
Post Translational Modifications
Function Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
Protein Name Kallikrein-8
Hk8
Neuropsin
Np
Ovasin
Serine Protease 19
Serine Protease Tadg-14
Tumor-Associated Differentially Expressed Gene 14 Protein
Database Links Reactome: R-HSA-6809371
Cellular Localisation Secreted
Cytoplasm
Shows A Cytoplasmic Distribution In The Keratinocytes
Alternative ELISA Names Kallikrein-8 ELISA kit
Hk8 ELISA kit
Neuropsin ELISA kit
Np ELISA kit
Ovasin ELISA kit
Serine Protease 19 ELISA kit
Serine Protease Tadg-14 ELISA kit
Tumor-Associated Differentially Expressed Gene 14 Protein ELISA kit
KLK8 ELISA kit
NRPN ELISA kit
PRSS19 ELISA kit
TADG14 ELISA kit
UNQ283 ELISA kit
PRO322 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance