• Human KLK6 (Kallikrein 6) Sandwich ELISA Kit Ready-To-Use (STJE0016585)

Human KLK6 (Kallikrein 6) Sandwich ELISA Kit Ready-To-Use (STJE0016585)

SKU:
STJE0016585

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.126ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This KLK6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: KLK6
Gene ID: 5653
Uniprot ID: KLK6_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cerebrospinal fluid, breast milk or other biological fluids.
Tissue Specificity In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
Post Translational Modifications Inactivated by autolytic cleavage after Arg-80.
Function Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Protein Name Kallikrein-6
Neurosin
Protease M
Sp59
Serine Protease 18
Serine Protease 9
Zyme
Database Links
Cellular Localisation Secreted
Nucleus
Nucleolus
Cytoplasm
Mitochondrion
Microsome
In Brain
Detected In The Nucleus Of Glial Cells And In The Nucleus And Cytoplasm Of Neurons
Detected In The Mitochondrial And Microsomal Fractions Of Hek-293 Cells And Released Into The Cytoplasm Following Cell Stress
Alternative ELISA Names Kallikrein-6 ELISA kit
Neurosin ELISA kit
Protease M ELISA kit
Sp59 ELISA kit
Serine Protease 18 ELISA kit
Serine Protease 9 ELISA kit
Zyme ELISA kit
KLK6 ELISA kit
PRSS18 ELISA kit
PRSS9 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance