• Human KIF14 (Kinesin Family, Member 14) Sandwich ELISA Kit (STJE0010151)

Human KIF14 (Kinesin Family, Member 14) Sandwich ELISA Kit (STJE0010151)

SKU:
STJE0010151

Shipping:
Free Shipping
Current Stock:
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.126ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This KIF14 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: KIF14
Gene ID: 9928
Uniprot ID: KIF14_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity. Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1. During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division. Also is required for chromosome congression and alignment during mitotic cell cycle process. Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules.
Protein Name Kinesin-Like Protein Kif14
Database Links Reactome: R-HSA-5625900
Reactome: R-HSA-9696270
Reactome: R-HSA-9696273
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Spindle
Midbody
Nuclear Localization Observed During Interphase
Nuclear Localization Triggered By Entry Into Mitosis
Cytoplasmic In Interphase
Cytoplasmic In Metaphase Cells
From Prophase To Metaphase
Accumulates At The Developing Spindle Poles And Their Associated Microtubules
During Anaphase
Accumulates At The Spindle Midzone
Localization To The Central Spindle And Midbody During Anaphase Is Dependent Upon Prc1 And Cit Presence
In Cells Ready To Undergo Abscission
Concentrates At The Contractile Ring
Alternative ELISA Names Kinesin-Like Protein Kif14 ELISA kit
KIF14 ELISA kit
KIAA0042 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance