• Human KARS (Lysyl tRNA Synthetase) Sandwich ELISA Kit Ready-To-Use (STJE0016518)

Human KARS (Lysyl tRNA Synthetase) Sandwich ELISA Kit Ready-To-Use (STJE0016518)

SKU:
STJE0016518

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.082ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This KARS Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: KARS1
Gene ID: 3735
Uniprot ID: SYK_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE).
Function Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
Protein Name Lysine--Trna Ligase
Lysyl-Trna Synthetase
Lysrs
Database Links Reactome: R-HSA-2408522
Reactome: R-HSA-379716
Reactome: R-HSA-379726
Cellular Localisation Isoform Cytoplasmic: Cytoplasm
Cytosol
Cytoplasm
Nucleus
Cell Membrane
Peripheral Membrane Protein
Secreted
Secretion Is Induced By Tnf-Alpha
Cytosolic In Quiescent Mast Cells
Translocates Into The Nucleus In Response To Mast Cell Activation By Immunoglobulin E
Isoform Mitochondrial: Mitochondrion
Alternative ELISA Names Lysine--Trna Ligase ELISA kit
Lysyl-Trna Synthetase ELISA kit
Lysrs ELISA kit
KARS1 ELISA kit
KARS ELISA kit
KIAA0070 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance