| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.054ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This JUP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | JUP |
| Gene ID: | 3728 |
| Uniprot ID: | PLAK_HUMAN |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Expressed in the heart (at protein level). |
| Post Translational Modifications | May be phosphorylated by FER. |
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. |
| Protein Name | Junction PlakoglobinCatenin GammaDesmoplakin IiiDesmoplakin-3 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013409Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionDesmosomeCytoplasmCytoskeletonMembranePeripheral Membrane ProteinCytoplasmic In A Soluble And Membrane-Associated Form |
| Alternative ELISA Names | Junction Plakoglobin ELISA kitCatenin Gamma ELISA kitDesmoplakin Iii ELISA kitDesmoplakin-3 ELISA kitJUP ELISA kitCTNNG ELISA kitDP3 ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
