• Human JUP (Junction Plakoglobin) Sandwich ELISA Kit Ready-To-Use (STJE0016516)

Human JUP (Junction Plakoglobin) Sandwich ELISA Kit Ready-To-Use (STJE0016516)

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STJE0016516

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.054ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This JUP Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: JUP
Gene ID: 3728
Uniprot ID: PLAK_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in the heart (at protein level).
Post Translational Modifications May be phosphorylated by FER.
Function Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Protein Name Junction Plakoglobin
Catenin Gamma
Desmoplakin Iii
Desmoplakin-3
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-5218920
Reactome: R-HSA-6798695
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013148
Reactome: R-HSA-9013406
Reactome: R-HSA-9013407
Reactome: R-HSA-9013409
Reactome: R-HSA-9762292
Reactome: R-HSA-9764302
Reactome: R-HSA-9833576
Cellular Localisation Cell Junction
Adherens Junction
Desmosome
Cytoplasm
Cytoskeleton
Membrane
Peripheral Membrane Protein
Cytoplasmic In A Soluble And Membrane-Associated Form
Alternative ELISA Names Junction Plakoglobin ELISA kit
Catenin Gamma ELISA kit
Desmoplakin Iii ELISA kit
Desmoplakin-3 ELISA kit
JUP ELISA kit
CTNNG ELISA kit
DP3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance