| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.133ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This JAM1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
F11R |
| Gene ID: |
50848 |
| Uniprot ID: |
JAM1_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in endothelium, epithelium and leukocytes (at protein level). |
| Post Translational Modifications | N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions. |
| Function | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. |
| Protein Name | Junctional Adhesion Molecule AJam-AJunctional Adhesion Molecule 1Jam-1Platelet F11 ReceptorPlatelet Adhesion Molecule 1Pam-1Cd Antigen Cd321 |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-2173791Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneSingle-Pass Type I Membrane ProteinLocalized At Tight Junctions Of Both Epithelial And Endothelial Cells |
| Alternative ELISA Names | Junctional Adhesion Molecule A ELISA kitJam-A ELISA kitJunctional Adhesion Molecule 1 ELISA kitJam-1 ELISA kitPlatelet F11 Receptor ELISA kitPlatelet Adhesion Molecule 1 ELISA kitPam-1 ELISA kitCd Antigen Cd321 ELISA kitF11R ELISA kitJAM1 ELISA kitJCAM ELISA kitUNQ264 ELISA kitPRO301 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
