• Human ITGa6 (Integrin Alpha 6) Sandwich ELISA Kit (STJE0010084)

Human ITGa6 (Integrin Alpha 6) Sandwich ELISA Kit (STJE0010084)

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STJE0010084

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ITGa6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ITGA6
Gene ID: 3655
Uniprot ID: ITA6_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines.they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Processed integrin alpha-6: Expressed at low levels in normal prostate tissue with elevated levels in prostate cancer tissue (at protein level).
Post Translational Modifications Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand. Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p). Production of alpha6p enhances prostate cancer cell invasion and migration. Palmitoylation by DHHC3 enhances stability and cell surface expression.
Function Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
Protein Name Integrin Alpha-6
Cd49 Antigen-Like Family Member F
Vla-6
Cd Antigen Cd49f Cleaved Into - Integrin Alpha-6 Heavy Chain - Integrin Alpha-6 Light Chain - Processed Integrin Alpha-6
Alpha6p
Database Links Reactome: R-HSA-2022090
Reactome: R-HSA-210991
Reactome: R-HSA-216083
Reactome: R-HSA-3000157
Reactome: R-HSA-3000170
Reactome: R-HSA-446107
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Lipid-Anchor
Alternative ELISA Names Integrin Alpha-6 ELISA kit
Cd49 Antigen-Like Family Member F ELISA kit
Vla-6 ELISA kit
Cd Antigen Cd49f Cleaved Into - Integrin Alpha-6 Heavy Chain - Integrin Alpha-6 Light Chain - Processed Integrin Alpha-6 ELISA kit
Alpha6p ELISA kit
ITGA6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance