Name: Human INVS protein (Recombinant) (N-GST) (STJP006239)
SKU: STJP006239
Availability: InStock

Human INVS protein (Recombinant) (N-GST) (STJP006239)

SKU:

STJP006239

£328.50 - £1,437.50

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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human INVS-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Post Translational Modifications	May be ubiquitinated via its interaction with APC2. Hydroxylated at Asn-75, most probably by HIF1AN.
Function	Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis.
Protein Name	Inversin Inversion Of Embryo Turning Homolog Nephrocystin-2
Cellular Localisation	Cytoplasm Cytoskeleton Spindle Membrane Peripheral Membrane Protein Nucleus Cell Projection Cilium Associates With Several Components Of The Cytoskeleton Including Ciliary Random And Polarized Microtubules During Mitosis It Is Recruited To Mitotic Spindle Frequently Membrane-Associated Membrane Localization Is Dependent Upon Cell-Cell Contacts And Is Redistributed When Cell Adhesion Is Disrupted After Incubation Of The Cell Monolayer With Low-Calcium/Egta Medium
Alternative Protein Names	Inversin protein Inversion Of Embryo Turning Homolog protein Nephrocystin-2 protein INVS protein INV protein NPHP2 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP003503	Human AGT protein (Recombinant) (N-GST) (STJP003503)	E. coli
STJP003471	Human F8 protein (Recombinant) (N-GST) (STJP003471)	E. coli
STJP003444	Human BAG3 protein (Recombinant) (N-GST) (STJP003444)	E. coli
STJP003829	Human NR3C2 protein (Recombinant) (N-GST) (STJP003829)	E. coli
STJP003877	Human CD63 protein (Recombinant) (N-GST) (STJP003877)	E. coli

Human INVS protein (Recombinant) (N-GST) (STJP006239)

General Information