• Human IL8 (Interleukin 8) Sandwich ELISA Kit (STJE0007133)

Human IL8 (Interleukin 8) Sandwich ELISA Kit (STJE0007133)

SKU:
STJE0007133

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 3.6pg/mL
Detection Limit: 7.81-500pg/mL
Short Description: This IL8 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: CXCL8
Gene ID: 3576
Uniprot ID: IL8_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. (Microbial infection) Cleaved by group A Streptococcus protease SpyCEP.leading to impaired neutrophil endothelial transmigration and thus increased virulence.
Function Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
Protein Name Interleukin-8
Il-8
C-X-C Motif Chemokine 8
Chemokine
C-X-C Motif Ligand 8
Emoctakin
Granulocyte Chemotactic Protein 1
Gcp-1
Monocyte-Derived Neutrophil Chemotactic Factor
Mdncf
Monocyte-Derived Neutrophil-Activating Peptide
Monap
Neutrophil-Activating Protein 1
Nap-1
Protein 3-10c
T-Cell Chemotactic Factor Cleaved Into - Mdncf-A
Gcp/Il-8 Protein Iv
Il8/Nap1 Form I - Interleukin-8
(Ala-Il-877
Gcp/Il-8 Protein Ii
Il-8(1-77
Il8/Nap1 Form Ii
Mdncf-B - Il-8(5-77 - Il-8(6-77
(Ser-Il-872
Gcp/Il-8 Protein I
Il8/Nap1 Form Iii
Lymphocyte-Derived Neutrophil-Activating Factor
Lynap
Mdncf-C
Neutrophil-Activating Factor
Naf - Il-8(7-77
Gcp/Il-8 Protein V
Il8/Nap1 Form Iv - Il-8(8-77
Gcp/Il-8 Protein Vi
Il8/Nap1 Form V - Il-8(9-77
Gcp/Il-8 Protein Iii
Il8/Nap1 Form Vi
Database Links Reactome: R-HSA-2559582
Reactome: R-HSA-375276
Reactome: R-HSA-380108
Reactome: R-HSA-380994
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Cellular Localisation Secreted
Alternative ELISA Names Interleukin-8 ELISA kit
Il-8 ELISA kit
C-X-C Motif Chemokine 8 ELISA kit
Chemokine ELISA kit
C-X-C Motif Ligand 8 ELISA kit
Emoctakin ELISA kit
Granulocyte Chemotactic Protein 1 ELISA kit
Gcp-1 ELISA kit
Monocyte-Derived Neutrophil Chemotactic Factor ELISA kit
Mdncf ELISA kit
Monocyte-Derived Neutrophil-Activating Peptide ELISA kit
Monap ELISA kit
Neutrophil-Activating Protein 1 ELISA kit
Nap-1 ELISA kit
Protein 3-10c ELISA kit
T-Cell Chemotactic Factor Cleaved Into - Mdncf-A ELISA kit
Gcp/Il-8 Protein Iv ELISA kit
Il8/Nap1 Form I - Interleukin-8 ELISA kit
(Ala-Il-877 ELISA kit
Gcp/Il-8 Protein Ii ELISA kit
Il-8(1-77 ELISA kit
Il8/Nap1 Form Ii ELISA kit
Mdncf-B - Il-8(5-77 - Il-8(6-77 ELISA kit
(Ser-Il-872 ELISA kit
Gcp/Il-8 Protein I ELISA kit
Il8/Nap1 Form Iii ELISA kit
Lymphocyte-Derived Neutrophil-Activating Factor ELISA kit
Lynap ELISA kit
Mdncf-C ELISA kit
Neutrophil-Activating Factor ELISA kit
Naf - Il-8(7-77 ELISA kit
Gcp/Il-8 Protein V ELISA kit
Il8/Nap1 Form Iv - Il-8(8-77 ELISA kit
Gcp/Il-8 Protein Vi ELISA kit
Il8/Nap1 Form V - Il-8(9-77 ELISA kit
Gcp/Il-8 Protein Iii ELISA kit
Il8/Nap1 Form Vi ELISA kit
CXCL8 ELISA kit
IL8 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance