• Human IL1F9 (Interleukin 1 Family, Member 9) Sandwich ELISA Kit (STJE0009850)

Human IL1F9 (Interleukin 1 Family, Member 9) Sandwich ELISA Kit (STJE0009850)

SKU:
STJE0009850

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.9pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This IL1F9 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: IL36G
Gene ID: 56300
Uniprot ID: IL36G_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin. Expressed in monocyte-derived dendritic cells and M1 macrophages.
Post Translational Modifications N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). Proteolytically cleaved by cathepsin CTSG.
Function Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1.also stimulates its own expression and that of the prototypic cutaneous pro-inflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.
Protein Name Interleukin-36 Gamma
Il-1-Related Protein 2
Il-1rp2
Interleukin-1 Epsilon
Il-1 Epsilon
Interleukin-1 Family Member 9
Il-1f9
Interleukin-1 Homolog 1
Il-1h1
Database Links Reactome: R-HSA-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative ELISA Names Interleukin-36 Gamma ELISA kit
Il-1-Related Protein 2 ELISA kit
Il-1rp2 ELISA kit
Interleukin-1 Epsilon ELISA kit
Il-1 Epsilon ELISA kit
Interleukin-1 Family Member 9 ELISA kit
Il-1f9 ELISA kit
Interleukin-1 Homolog 1 ELISA kit
Il-1h1 ELISA kit
IL36G ELISA kit
IL1E ELISA kit
IL1F9 ELISA kit
IL1H1 ELISA kit
IL1RP2 ELISA kit
UNQ2456 ELISA kit
PRO5737 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance