| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.055ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This IL12Rb2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
IL12RB2 |
| Gene ID: |
3595 |
| Uniprot ID: |
I12R2_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Isoform 2 is expressed at similar levels in both naive and activated T-cells. |
| Post Translational Modifications | On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. |
| Function | Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-2Il-12 Receptor Subunit Beta-2Il-12r Subunit Beta-2Il-12r-Beta-2Il-12rb2 |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020591 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative ELISA Names | Interleukin-12 Receptor Subunit Beta-2 ELISA kitIl-12 Receptor Subunit Beta-2 ELISA kitIl-12r Subunit Beta-2 ELISA kitIl-12r-Beta-2 ELISA kitIl-12rb2 ELISA kitIL12RB2 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
