Human IGFBP1 protein (Recombinant) (C-His) (STJP003871)

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STJP003871
£469.50 - £2,492.50
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IGFBP1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IGFBP1
Gene ID: 3484
Uniprot ID: IBP1_HUMAN
Immunogen Region: Met1-Asn259
Immunogen: Homo sapiens (Human)
Function Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Plays also a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway. Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation.
Protein Name Insulin-Like Growth Factor-Binding Protein 1
Ibp-1
Igf-Binding Protein 1
Igfbp-1
Placental Protein 12
Pp12
Database Links Reactome: R-HSA-380994
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Reactome: R-HSA-9615017
Cellular Localisation Secreted
Alternative Protein Names Insulin-Like Growth Factor-Binding Protein 1 protein
Ibp-1 protein
Igf-Binding Protein 1 protein
Igfbp-1 protein
Placental Protein 12 protein
Pp12 protein
IGFBP1 protein
IBP1 protein

Information sourced from Uniprot.org

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