| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.001 EU/Mu g |
| Gene Symbol: |
IGFBP5 |
| Gene ID: |
3488 |
| Uniprot ID: |
IBP5_HUMAN |
| Immunogen Region: |
Leu21-Glu272 |
| Immunogen: |
Recombinant human IGFBP-5 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu21-Glu272) of human IGFBP5 (Accession #NP_000590.1) fused with and a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
MAQRCFHSEYFDSLLHACKP CRLRCSNPPAPCQPYCDPSM TSSVRGTYT |
| Tissue Specificity | Osteosarcoma, and at lower levels in liver, kidney and brain. |
| Post Translational Modifications | Cleaved by C1S in extracellular space. |
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells. Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling. Plays also a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 5Ibp-5Igf-Binding Protein 5Igfbp-5 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedCytoplasmNucleus |
| Alternative Protein Names | Insulin-Like Growth Factor-Binding Protein 5 proteinIbp-5 proteinIgf-Binding Protein 5 proteinIgfbp-5 proteinIGFBP5 proteinIBP5 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
