• Human ICOS (Inducible T-Cell Co Stimulator) Sandwich ELISA Kit Ready-To-Use (STJE0016016)

Human ICOS (Inducible T-Cell Co Stimulator) Sandwich ELISA Kit Ready-To-Use (STJE0016016)

SKU:
STJE0016016

Shipping:
Free Shipping
Current Stock:
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 6.2pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This ICOS Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ICOS
Gene ID: 29851
Uniprot ID: ICOS_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, urine, cell lysates or other biological fluids.
Tissue Specificity Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Post Translational Modifications N-glycosylated.
Function Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Protein Name Inducible T-Cell Costimulator
Activation-Inducible Lymphocyte Immunomediatory Molecule
Cd Antigen Cd278
Database Links Reactome: R-HSA-1257604 Q9Y6W8-1
Reactome: R-HSA-2219530 Q9Y6W8-1
Reactome: R-HSA-388841 Q9Y6W8-1
Reactome: R-HSA-6811558 Q9Y6W8-1
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative ELISA Names Inducible T-Cell Costimulator ELISA kit
Activation-Inducible Lymphocyte Immunomediatory Molecule ELISA kit
Cd Antigen Cd278 ELISA kit
ICOS ELISA kit
AILIM ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance