• Human HMGN1 (High Mobility Group Nucleosome Binding Domain Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0015863)

Human HMGN1 (High Mobility Group Nucleosome Binding Domain Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0015863)

SKU:
STJE0015863

£462.50 - £632.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.114ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This HMGN1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: HMGN1
Gene ID: 3150
Uniprot ID: HMGN1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation. Phosphorylation favors cytoplasmic localization.
Function Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.
Protein Name Non-Histone Chromosomal Protein Hmg-14
High Mobility Group Nucleosome-Binding Domain-Containing Protein 1
Database Links Reactome: R-HSA-6781823
Reactome: R-HSA-6781827
Reactome: R-HSA-6782135
Reactome: R-HSA-6782210
Cellular Localisation Nucleus
Cytoplasm
Cytoplasmic Enrichment Upon Phosphorylation
The Rna Edited Version Localizes To The Nucleus
Alternative ELISA Names Non-Histone Chromosomal Protein Hmg-14 ELISA kit
High Mobility Group Nucleosome-Binding Domain-Containing Protein 1 ELISA kit
HMGN1 ELISA kit
HMG14 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance