• Human HK1 (Hexokinase 1) Sandwich ELISA Kit Ready-To-Use (STJE0015848)

Human HK1 (Hexokinase 1) Sandwich ELISA Kit Ready-To-Use (STJE0015848)

SKU:
STJE0015848

£443.50 - £605.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 27.2pg/mL
Detection Limit: 62.5-4000pg/mL
Short Description: This HK1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: HK1
Gene ID: 3098
Uniprot ID: HXK1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Isoform 2: Erythrocyte specific (Ref.6). Isoform 3: Testis-specific. Isoform 4: Testis-specific.
Post Translational Modifications
Function Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine. Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome.
Protein Name Hexokinase-1
Brain Form Hexokinase
Hexokinase Type I
Hk I
Hexokinase-A
Database Links Reactome: R-HSA-5619056
Reactome: R-HSA-70171
Cellular Localisation Mitochondrion Outer Membrane
Peripheral Membrane Protein
Cytoplasm
Cytosol
The Mitochondrial-Binding Peptide (Mbp) Region Promotes Association With The Mitochondrial Outer Membrane (Probable)
Dissociates From The Mitochondrial Outer Membrane Following Inhibition By N-Acetyl-D-Glucosamine
Leading To Relocation To The Cytosol
Alternative ELISA Names Hexokinase-1 ELISA kit
Brain Form Hexokinase ELISA kit
Hexokinase Type I ELISA kit
Hk I ELISA kit
Hexokinase-A ELISA kit
HK1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance