| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.058ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This HEXb Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
HEXB |
| Gene ID: |
3074 |
| Uniprot ID: |
HEXB_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | N-linked glycans at Asn-142 and Asn-190 consist of Man(3)-GlcNAc(2) and Man(5 to 7)-GlcNAc(2), respectively. The beta-A and beta-B chains are produced by proteolytic processing of the precursor beta chain. |
| Function | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida. |
| Protein Name | Beta-Hexosaminidase Subunit BetaBeta-N-Acetylhexosaminidase Subunit BetaHexosaminidase Subunit BCervical Cancer Proto-Oncogene 7 ProteinHcc-7N-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A |
| Database Links | Reactome: R-HSA-1660662Reactome: R-HSA-2022857Reactome: R-HSA-2024101Reactome: R-HSA-2160916Reactome: R-HSA-3656248Reactome: R-HSA-6798695 |
| Cellular Localisation | LysosomeCytoplasmic VesicleSecretory VesicleCortical Granule |
| Alternative ELISA Names | Beta-Hexosaminidase Subunit Beta ELISA kitBeta-N-Acetylhexosaminidase Subunit Beta ELISA kitHexosaminidase Subunit B ELISA kitCervical Cancer Proto-Oncogene 7 Protein ELISA kitHcc-7 ELISA kitN-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A ELISA kitHEXB ELISA kitHCC7 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
