• Human GRIA3 (Glutamate Receptor, Ionotropic, AMPA 3) Sandwich ELISA Kit Ready-To-Use (STJE0015676)

Human GRIA3 (Glutamate Receptor, Ionotropic, AMPA 3) Sandwich ELISA Kit Ready-To-Use (STJE0015676)

SKU:
STJE0015676

Shipping:
Free Shipping
Current Stock:
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.116ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This GRIA3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: GRIA3
Gene ID: 2892
Uniprot ID: GRIA3_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Protein Name Glutamate Receptor 3
Glur-3
Ampa-Selective Glutamate Receptor 3
Glur-C
Glur-K3
Glutamate Receptor Ionotropic - Ampa 3
Glua3
Database Links Reactome: R-HSA-399710
Reactome: R-HSA-399719
Reactome: R-HSA-416993
Reactome: R-HSA-438066
Reactome: R-HSA-8849932
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Interaction With Cnih2 And Cnih3 Promotes Cell Surface Expression
Alternative ELISA Names Glutamate Receptor 3 ELISA kit
Glur-3 ELISA kit
Ampa-Selective Glutamate Receptor 3 ELISA kit
Glur-C ELISA kit
Glur-K3 ELISA kit
Glutamate Receptor Ionotropic - Ampa 3 ELISA kit
Glua3 ELISA kit
GRIA3 ELISA kit
GLUR3 ELISA kit
GLURC ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance