| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human GFRAL-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications. |
| Formulation: |
Lyophilized from 0.22um filtered solution in 20mM PB, 300mM NaCl (pH 6.5). Normally 5 % trehalose is added as protectant before lyophilization. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GFRAL |
| Gene ID: |
389400 |
| Uniprot ID: |
GFRAL_HUMAN |
| Immunogen Region: |
Ser19-Glu351 |
| Immunogen: |
Recombinant Human GFRAL Protein is produced by mammalian expression system. The target protein is expressed with sequence (Ser19-Glu351) of human GFRAL (Accession #) fused with a His and Avi Tag at the C-terminal.. |
| Function | Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. |
| Protein Name | Gdnf Family Receptor Alpha-Like |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinExtracellular Side |
| Alternative Protein Names | Gdnf Family Receptor Alpha-Like proteinGFRAL proteinC6orf144 proteinUNQ9356 proteinPRO34128 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
