• Human GDF5 (Growth Differentiation Factor 5) Sandwich ELISA Kit (STJE0009119)

Human GDF5 (Growth Differentiation Factor 5) Sandwich ELISA Kit (STJE0009119)

SKU:
STJE0009119

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.064ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This GDF5 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: GDF5
Gene ID: 8200
Uniprot ID: GDF5_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level).
Post Translational Modifications
Function Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Protein Name Growth/Differentiation Factor 5
Gdf-5
Bone Morphogenetic Protein 14
Bmp-14
Cartilage-Derived Morphogenetic Protein 1
Cdmp-1
Lipopolysaccharide-Associated Protein 4
Lap-4
Lps-Associated Protein 4
Radotermin
Database Links Reactome: R-HSA-2129379
Cellular Localisation Secreted
Cell Membrane
Alternative ELISA Names Growth/Differentiation Factor 5 ELISA kit
Gdf-5 ELISA kit
Bone Morphogenetic Protein 14 ELISA kit
Bmp-14 ELISA kit
Cartilage-Derived Morphogenetic Protein 1 ELISA kit
Cdmp-1 ELISA kit
Lipopolysaccharide-Associated Protein 4 ELISA kit
Lap-4 ELISA kit
Lps-Associated Protein 4 ELISA kit
Radotermin ELISA kit
GDF5 ELISA kit
BMP14 ELISA kit
CDMP1 ELISA kit
output

Information sourced from Uniprot.org