| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
4.39 pg/mL |
| Detection Limit: |
78-500 pg/ml |
| Short Description: |
This GDF15 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Conjugation: |
Biotin |
| Storage Instruction: |
Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
| Assay Time: |
4 hours |
| Detection: |
Colorimetric |
| Gene Symbol: |
GDF15 |
| Gene ID: |
9518 |
| Uniprot ID: |
GDF15_HUMAN |
| Sample Type: |
serum, plasma and cell culture supernates |
| Tissue Specificity | Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Detected in plasma (at protein level). |
| Post Translational Modifications | |
| Function | Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling. |
| Protein Name | Growth/Differentiation Factor 15Gdf-15Macrophage Inhibitory Cytokine 1Mic-1Nsaid-Activated Gene 1 ProteinNag-1Nsaid-Regulated Gene 1 ProteinNrg-1Placental Tgf-BetaPlacental Bone Morphogenetic ProteinProstate Differentiation Factor |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Growth/Differentiation Factor 15 ELISA kitGdf-15 ELISA kitMacrophage Inhibitory Cytokine 1 ELISA kitMic-1 ELISA kitNsaid-Activated Gene 1 Protein ELISA kitNag-1 ELISA kitNsaid-Regulated Gene 1 Protein ELISA kitNrg-1 ELISA kitPlacental Tgf-Beta ELISA kitPlacental Bone Morphogenetic Protein ELISA kitProstate Differentiation Factor ELISA kitGDF15 ELISA kitMIC1 ELISA kitPDF ELISA kitPLAB ELISA kitPTGFB ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
