Human GAS-6 protein (Recombinant) (C-His) (STJP002483)

SKU:
STJP002483-100

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Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human GAS-6-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM Tris, 500mM NaCl (pH 8.5).
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Immobilized Human GAS6, His Tag at 5 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Human Axl with the EC50 of 7.5ng/ml determined by ELISA.
Gene Symbol: GAS6
Gene ID: 2621
Uniprot ID: GAS6_HUMAN
Immunogen Region: Ala49-Ala678
Immunogen: Recombinant Human GAS-6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala49-Ala678) of human GAS-6 (Accession #NP_000811.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Isoform 2: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
Function Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry.
Protein Name Growth Arrest-Specific Protein 6
Gas-6
Axl Receptor Tyrosine Kinase Ligand
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-159740
Reactome: R-HSA-159763
Reactome: R-HSA-159782
Reactome: R-HSA-202733
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Secreted
Alternative Protein Names Growth Arrest-Specific Protein 6 protein
Gas-6 protein
Axl Receptor Tyrosine Kinase Ligand protein
GAS6 protein
AXLLG protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance