• Human FZD1 (Frizzled Homolog 1) Sandwich ELISA Kit Ready-To-Use (STJE0015396)

Human FZD1 (Frizzled Homolog 1) Sandwich ELISA Kit Ready-To-Use (STJE0015396)

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STJE0015396

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.053ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This FZD1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: FZD1
Gene ID: 8321
Uniprot ID: FZD1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.
Post Translational Modifications Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Function Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B. Contradictory results showing activation by WNT7B have been described for mouse. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.
Protein Name Frizzled-1
Fz-1
Hfz1
Fze1
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-373080
Reactome: R-HSA-4086400
Reactome: R-HSA-4608870
Reactome: R-HSA-4641262
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Frizzled-1 ELISA kit
Fz-1 ELISA kit
Hfz1 ELISA kit
Fze1 ELISA kit
FZD1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance