• Human FOLR1 (Folate Receptor 1, Adult) Sandwich ELISA Kit Ready-To-Use (STJE0015339)

Human FOLR1 (Folate Receptor 1, Adult) Sandwich ELISA Kit Ready-To-Use (STJE0015339)

SKU:
STJE0015339

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.8pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This FOLR1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: FOLR1
Gene ID: 2348
Uniprot ID: FOLR1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
Post Translational Modifications The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Protein Name Folate Receptor Alpha
Fr-Alpha
Adult Folate-Binding Protein
Fbp
Folate Receptor 1
Folate Receptor - Adult
Kb Cells Fbp
Ovarian Tumor-Associated Antigen Mov18
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-5694530
Reactome: R-HSA-6807878
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Basolateral Cell Membrane
Gpi-Like-Anchor
Secreted
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Endosome
Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane
Alternative ELISA Names Folate Receptor Alpha ELISA kit
Fr-Alpha ELISA kit
Adult Folate-Binding Protein ELISA kit
Fbp ELISA kit
Folate Receptor 1 ELISA kit
Folate Receptor - Adult ELISA kit
Kb Cells Fbp ELISA kit
Ovarian Tumor-Associated Antigen Mov18 ELISA kit
FOLR1 ELISA kit
FOLR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance