• Human FNBP1 (Formin Binding Protein 1) Sandwich ELISA Kit (STJE0008956)

Human FNBP1 (Formin Binding Protein 1) Sandwich ELISA Kit (STJE0008956)

SKU:
STJE0008956

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.056ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This FNBP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: FNBP1
Gene ID: 23048
Uniprot ID: FNBP1_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
Post Translational Modifications
Function May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
Protein Name Formin-Binding Protein 1
Formin-Binding Protein 17
Hfbp17
Database Links Reactome: R-HSA-8856828
Reactome: R-HSA-9013148
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Reactome: R-HSA-9696270
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Cortex
Lysosome
Cytoplasmic Vesicle
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Membrane
Clathrin-Coated Pit
Enriched In Cortical Regions Coincident With F-Actin
Also Localizes To Endocytic Vesicles And Lysosomes
Alternative ELISA Names Formin-Binding Protein 1 ELISA kit
Formin-Binding Protein 17 ELISA kit
Hfbp17 ELISA kit
FNBP1 ELISA kit
FBP17 ELISA kit
KIAA0554 ELISA kit
output

Information sourced from Uniprot.org

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