| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.061ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This FKBP5 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
FKBP5 |
| Gene ID: |
2289 |
| Uniprot ID: |
FKBP5_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Widely expressed, enriched in testis compared to other tissues. |
| Post Translational Modifications | Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation. |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5Ppiase Fkbp551 Kda Fk506-Binding Protein51 Kda FkbpFkbp-5154 Kda Progesterone Receptor-Associated ImmunophilinAndrogen-Regulated Protein 6Ff1 AntigenFk506-Binding Protein 5Fkbp-5Fkbp54P54Hsp90-Binding ImmunophilinRotamase |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-8939211Reactome: R-HSA-9022699 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative ELISA Names | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5 ELISA kitPpiase Fkbp5 ELISA kit51 Kda Fk506-Binding Protein ELISA kit51 Kda Fkbp ELISA kitFkbp-51 ELISA kit54 Kda Progesterone Receptor-Associated Immunophilin ELISA kitAndrogen-Regulated Protein 6 ELISA kitFf1 Antigen ELISA kitFk506-Binding Protein 5 ELISA kitFkbp-5 ELISA kitFkbp54 ELISA kitP54 ELISA kitHsp90-Binding Immunophilin ELISA kitRotamase ELISA kitFKBP5 ELISA kitAIG6 ELISA kitFKBP51 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
