• Human FGF1 (Fibroblast Growth Factor 1, Acidic) Sandwich ELISA Kit Ready-To-Use (STJE0006884)

Human FGF1 (Fibroblast Growth Factor 1, Acidic) Sandwich ELISA Kit Ready-To-Use (STJE0006884)

SKU:
STJE0006884

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.61pg/mL
Detection Limit: 1.56-100pg/mL
Short Description: This FGF1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: FGF1
Gene ID: 2246
Uniprot ID: FGF1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Post Translational Modifications In the nucleus, phosphorylated by PKC/PRKCD.
Function Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.
Protein Name Fibroblast Growth Factor 1
Fgf-1
Acidic Fibroblast Growth Factor
Afgf
Endothelial Cell Growth Factor
Ecgf
Heparin-Binding Growth Factor 1
Hbgf-1
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-1839122
Reactome: R-HSA-1839130
Reactome: R-HSA-190322
Reactome: R-HSA-190370
Reactome: R-HSA-190371
Reactome: R-HSA-190372
Reactome: R-HSA-190373
Reactome: R-HSA-190375
Reactome: R-HSA-190377
Reactome: R-HSA-2033519
Reactome: R-HSA-2219530
Reactome: R-HSA-5654219
Reactome: R-HSA-5654221
Reactome: R-HSA-5654227
Reactome: R-HSA-5654228
Reactome: R-HSA-5654687
Reactome: R-HSA-5654688
Reactome: R-HSA-5654689
Reactome: R-HSA-5654693
Reactome: R-HSA-5654695
Reactome: R-HSA-5654699
Reactome: R-HSA-5654700
Reactome: R-HSA-5654704
Reactome: R-HSA-5654706
Reactome: R-HSA-5654710
Reactome: R-HSA-5654712
Reactome: R-HSA-5654719
Reactome: R-HSA-5654720
Reactome: R-HSA-5654726
Reactome: R-HSA-5654727
Reactome: R-HSA-5654732
Reactome: R-HSA-5654733
Reactome: R-HSA-5655253
Reactome: R-HSA-5655302
Reactome: R-HSA-5655332
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-8851708
Cellular Localisation Secreted
Cytoplasm
Cell Cortex
Cytosol
Nucleus
Lacks A Cleavable Signal Sequence
Within The Cytoplasm
It Is Transported To The Cell Membrane And Then Secreted By A Non-Classical Pathway That Requires Cu(2+) Ions And S100a13
Secreted In A Complex With Syt1
Binding Of Exogenous Fgf1 To Fgfr Facilitates Endocytosis Followed By Translocation Of Fgf1 Across Endosomal Membrane Into The Cytosol
Nuclear Import From The Cytosol Requires The Classical Nuclear Import Machinery
Involving Proteins Kpna1 And Kpnb1
As Well As Lrrc59
Alternative ELISA Names Fibroblast Growth Factor 1 ELISA kit
Fgf-1 ELISA kit
Acidic Fibroblast Growth Factor ELISA kit
Afgf ELISA kit
Endothelial Cell Growth Factor ELISA kit
Ecgf ELISA kit
Heparin-Binding Growth Factor 1 ELISA kit
Hbgf-1 ELISA kit
FGF1 ELISA kit
FGFA ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance