| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.058ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This FAM132A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
C1qtnf12 |
| Gene ID: |
67389 |
| Uniprot ID: |
ADIPL_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Widely expressed, with high expression in subcutaneous and epididymal white adipose tissues and brown adipose tissue. Expressed in adipocytes (at protein level). |
| Post Translational Modifications | Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN. Insulin enhances endogenous C1QTNF12 cleavage. |
| Function | Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. Adipolin fC1QTNF12: Acts by activating the Akt signaling in hepatocytes and adipocytes. Not able to increase insulin-stimulated glucose uptake in adipocytes. Adipolin gC1QTNF12: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes. |
| Protein Name | AdipolinAdipose-Derived Insulin-Sensitizing FactorComplement C1q Tumor Necrosis Factor-Related Protein 12 Cleaved Into - Adipolin Fc1qtnf12Adipolin Fctrp12Adipolin Full-Length Form - Adipolin Gc1qtnf12Adipolin Cleaved FormAdipolin Gctrp12 |
| Database Links | |
| Cellular Localisation | Adipolin Fc1qtnf12: SecretedAdipolin Gc1qtnf12: SecretedIn Serum Is The Predominant Form |
| Alternative ELISA Names | Adipolin ELISA kitAdipose-Derived Insulin-Sensitizing Factor ELISA kitComplement C1q Tumor Necrosis Factor-Related Protein 12 Cleaved Into - Adipolin Fc1qtnf12 ELISA kitAdipolin Fctrp12 ELISA kitAdipolin Full-Length Form - Adipolin Gc1qtnf12 ELISA kitAdipolin Cleaved Form ELISA kitAdipolin Gctrp12 ELISA kitC1qtnf12 ELISA kitC1qdc2 ELISA kitCtrp12 ELISA kitFam132a ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
