• Human ERRa (Estrogen Related Receptor Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015083)

Human ERRa (Estrogen Related Receptor Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015083)

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STJE0015083

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.127ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ERRa Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ESRRA
Gene ID: 2101
Uniprot ID: ERR1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding. Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity.deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
Function Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Protein Name Steroid Hormone Receptor Err1
Estrogen Receptor-Like 1
Estrogen-Related Receptor Alpha
Err-Alpha
Nuclear Receptor Subfamily 3 Group B Member 1
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2151201
Reactome: R-HSA-383280
Reactome: R-HSA-8939902
Cellular Localisation Nucleus
Cytoplasm
Co-Localizes To The Cytoplasm Only In Presence Of Mapk15
Alternative ELISA Names Steroid Hormone Receptor Err1 ELISA kit
Estrogen Receptor-Like 1 ELISA kit
Estrogen-Related Receptor Alpha ELISA kit
Err-Alpha ELISA kit
Nuclear Receptor Subfamily 3 Group B Member 1 ELISA kit
ESRRA ELISA kit
ERR1 ELISA kit
ESRL1 ELISA kit
NR3B1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance