Name: Human EED protein (Recombinant) (N-His) (STJP003361)
SKU: STJP003361
Availability: InStock

Human EED protein (Recombinant) (N-His) (STJP003361)

SKU:

STJP003361

£328.50 - £1,437.50

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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human EED-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Post Translational Modifications	Methylated. Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines.
Function	Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Protein Name	Polycomb Protein Eed Heed Embryonic Ectoderm Development Protein Wd Protein Associating With Integrin Cytoplasmic Tails 1 Wait-1
Database Links	Reactome: R-HSA-212300 Reactome: R-HSA-2559580 Reactome: R-HSA-3214841 Reactome: R-HSA-5617472 Reactome: R-HSA-8943724 Reactome: R-HSA-8953750 Reactome: R-HSA-9609690 Reactome: R-HSA-9710421
Cellular Localisation	Nucleus Chromosome Transiently Colocalizes With Xist At Inactive X Chromosomes
Alternative Protein Names	Polycomb Protein Eed protein Heed protein Embryonic Ectoderm Development Protein protein Wd Protein Associating With Integrin Cytoplasmic Tails 1 protein Wait-1 protein EED protein

Information sourced from Uniprot.org

Model	Name	Host
STJP005172	Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172)	E. coli
STJP004723	Human WAS protein (Recombinant) (N-His) (STJP004723)	E. coli
STJP002980	Human KLHL20 protein (Recombinant) (N-His) (STJP002980)	HEK293 cells
STJP003027	Human CCL3L1 protein (Recombinant) (N-His) (STJP003027)	HEK293 cells
STJP003488	Human CFD protein (Recombinant) (N-His) (STJP003488)	E. coli

Human EED protein (Recombinant) (N-His) (STJP003361)