| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
47pg/mL |
| Detection Limit: |
125-8000pg/mL |
| Short Description: |
This dSIP Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
TSC22D3 |
| Gene ID: |
1831 |
| Uniprot ID: |
T22D3_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Ubiquitously expressed, including in the fetal brain and liver. Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells. |
| Post Translational Modifications | |
| Function | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities. In vitro, suppresses AP-1 transcription factor complex DNA-binding activities. Isoform 1: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. |
| Protein Name | Tsc22 Domain Family Protein 3Dsip-Immunoreactive PeptideProtein DipHdipDelta Sleep-Inducing Peptide ImmunoreactorGlucocorticoid-Induced Leucine Zipper ProteinGilzTsc-22-Like ProteinTsc-22-Related ProteinTsc-22r |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusLocalization Depends On Differentiation Status Of MyoblastsIn Undifferentiated MyoblastsLocalizes To The CytoplasmBut In Differentiating MyoblastLocalizes To The Nucleus |
| Alternative ELISA Names | Tsc22 Domain Family Protein 3 ELISA kitDsip-Immunoreactive Peptide ELISA kitProtein Dip ELISA kitHdip ELISA kitDelta Sleep-Inducing Peptide Immunoreactor ELISA kitGlucocorticoid-Induced Leucine Zipper Protein ELISA kitGilz ELISA kitTsc-22-Like Protein ELISA kitTsc-22-Related Protein ELISA kitTsc-22r ELISA kitTSC22D3 ELISA kitDSIPI ELISA kitGILZ ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
