| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.117ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This DPP8 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
DPP8 |
| Gene ID: |
54878 |
| Uniprot ID: |
DPP8_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. |
| Post Translational Modifications | |
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8.however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition. |
| Protein Name | Dipeptidyl Peptidase 8Dp8Dipeptidyl Peptidase Iv-Related Protein 1Dprp-1Dipeptidyl Peptidase ViiiDpp ViiiProlyl Dipeptidase Dpp8 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Dipeptidyl Peptidase 8 ELISA kitDp8 ELISA kitDipeptidyl Peptidase Iv-Related Protein 1 ELISA kitDprp-1 ELISA kitDipeptidyl Peptidase Viii ELISA kitDpp Viii ELISA kitProlyl Dipeptidase Dpp8 ELISA kitDPP8 ELISA kitDPRP1 ELISA kitMSTP097 ELISA kitMSTP135 ELISA kitMSTP141 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
