• Human DNASE1L3 (Deoxyribonuclease I Like Protein 3) Sandwich ELISA Kit Ready-To-Use (STJE0014853)

Human DNASE1L3 (Deoxyribonuclease I Like Protein 3) Sandwich ELISA Kit Ready-To-Use (STJE0014853)

SKU:
STJE0014853

£518.50 - £713.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.065ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This DNASE1L3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: DNASE1L3
Gene ID: 1776
Uniprot ID: DNSL3_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Liver and spleen.
Post Translational Modifications Poly-ADP-ribosylated by PARP1. ADP-ribosylation negatively regulates enzymatic activity during apoptosis.
Function Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity. Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation.
Protein Name Deoxyribonuclease Gamma
Dnase Gamma
Dnase I Homolog Protein Dhp2
Deoxyribonuclease I-Like 3
Dnase I-Like 3
Liver And Spleen Dnase
Ls-Dnase
Lsd
Database Links
Cellular Localisation Nucleus
Endoplasmic Reticulum
Secreted
Translocates From The Endoplasmic Reticulum To The Nucleus During Apoptosis
Contradictory Reports Exist About The Subcellular Localization Under Normal Physiological Conditions
Under Conditions Of Cell Death
May Diffuse And/Or Be Actively Transported To The Nucleus
Alternative ELISA Names Deoxyribonuclease Gamma ELISA kit
Dnase Gamma ELISA kit
Dnase I Homolog Protein Dhp2 ELISA kit
Deoxyribonuclease I-Like 3 ELISA kit
Dnase I-Like 3 ELISA kit
Liver And Spleen Dnase ELISA kit
Ls-Dnase ELISA kit
Lsd ELISA kit
DNASE1L3 ELISA kit
DHP2 ELISA kit
DNAS1L3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance