Human DKK1 (Dickkopf-Related Protein 1) Antibody Pair (STJAP00492)

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STJAP00492-50
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Host: Rabbit/Rabbit
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This DKK1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Determination Method: Colormetric
Gene Symbol: DKK1
Gene ID: 22943
Uniprot ID: DKK1_HUMAN
Immunogen: Capture immunogen: Recombinant Human DKK1 protien.
Detection Immunogen: Recombinant Human DKK1 protien.
Sample Type: Serum, plasma and other biological fluids
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.
Protein Name Dickkopf-Related Protein 1
Dickkopf-1
Dkk-1
Hdkk-1
Sk
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-5339717
Cellular Localisation Secreted
Alternative Antibody Pair Names Dickkopf-Related Protein 1 antibody pair
Dickkopf-1 antibody pair
Dkk-1 antibody pair
Hdkk-1 antibody pair
Sk antibody pair
DKK1 antibody pair
UNQ492 antibody pair
PRO1008 antibody pair

Information sourced from Uniprot.org

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