| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.31ng/mL |
| Detection Limit: |
0.781-50ng/mL |
| Short Description: |
This DCD Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
DCD |
| Gene ID: |
117159 |
| Uniprot ID: |
DCD_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Detected in urine (at protein level). Constitutively expressed in eccrine sweat gland cells (at protein level). Secreted into the sweat at a concentration of 1-10 micrograms/ml. |
| Post Translational Modifications | |
| Function | DCD-1: Found in sweat, has an antimicrobial activity during early bacterial colonization. The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes. Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues. Survival-promoting peptide: Promotes survival of neurons and displays phosphatase activity. It may bind IgG. |
| Protein Name | DermcidinPreproteolysin Cleaved Into - Survival-Promoting Peptide - Dcd-1 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedSurvival-Promoting Peptide: SecretedDcd-1: SecretedMembranePeripheral Membrane ProteinSingle-Pass Membrane ProteinThe Secreted Peptide Assembles Into Homohexameric Complexes That Can Probably Associate With Pathogen Membranes And Also Insert Into These Membranes Where They Behave As Channels |
| Alternative ELISA Names | Dermcidin ELISA kitPreproteolysin Cleaved Into - Survival-Promoting Peptide - Dcd-1 ELISA kitDCD ELISA kitAIDD ELISA kitDSEP ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
