• Human CSNK1d (Casein Kinase 1 Delta) Sandwich ELISA Kit (STJE0008190)

Human CSNK1d (Casein Kinase 1 Delta) Sandwich ELISA Kit (STJE0008190)

SKU:
STJE0008190

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.052ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CSNK1d Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: CSNK1D
Gene ID: 1453
Uniprot ID: KC1D_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
Post Translational Modifications Autophosphorylated on serine and threonine residues.this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.
Function Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.
Protein Name Casein Kinase I Isoform Delta
Cki-Delta
Ckid
Tau-Protein Kinase Csnk1d
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-2565942
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-400253
Reactome: R-HSA-5620912
Reactome: R-HSA-6791226
Reactome: R-HSA-8854518
Cellular Localisation Cytoplasm
Nucleus
Cytoskeleton
Microtubule Organizing Center
Centrosome
Perinuclear Region
Cell Membrane
Spindle
Golgi Apparatus
Localized At Mitotic Spindle Microtubules
And At The Centrosomes And Interphase In Interphase Cells
Recruited To The Spindle Apparatus And The Centrosomes In Response To Dna-Damage
Correct Subcellular Localization Requires Kinase Activity
Alternative ELISA Names Casein Kinase I Isoform Delta ELISA kit
Cki-Delta ELISA kit
Ckid ELISA kit
Tau-Protein Kinase Csnk1d ELISA kit
CSNK1D ELISA kit
HCKID ELISA kit
output

Information sourced from Uniprot.org

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