| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 9Cell Differentiation Protein Rqcd1 HomologRcd-1 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-5617472Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | NucleusCytoplasmP-BodyNanos2 Promotes Its Localization To P-Body |
| Alternative Protein Names | Ccr4-Not Transcription Complex Subunit 9 proteinCell Differentiation Protein Rqcd1 Homolog proteinRcd-1 proteinCNOT9 proteinRCD1 proteinRQCD1 protein |
Information sourced from Uniprot.org
