Human CNOT9 protein (Recombinant) (N-His) (STJP008347)

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STJP008347
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CNOT9-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CNOT9
Gene ID: 9125
Uniprot ID: CNOT9_HUMAN
Immunogen Region: Thr12-Glu285
Immunogen: Homo sapiens (Human)
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
Protein Name Ccr4-Not Transcription Complex Subunit 9
Cell Differentiation Protein Rqcd1 Homolog
Rcd-1
Database Links Reactome: R-HSA-429947
Reactome: R-HSA-5617472
Reactome: R-HSA-6804115
Reactome: R-HSA-9820841
Cellular Localisation Nucleus
Cytoplasm
P-Body
Nanos2 Promotes Its Localization To P-Body
Alternative Protein Names Ccr4-Not Transcription Complex Subunit 9 protein
Cell Differentiation Protein Rqcd1 Homolog protein
Rcd-1 protein
CNOT9 protein
RCD1 protein
RQCD1 protein

Information sourced from Uniprot.org