| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.039ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This CLEC4K Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
CD207 |
| Gene ID: |
50489 |
| Uniprot ID: |
CLC4K_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. |
| Post Translational Modifications | |
| Function | Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs).is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. |
| Protein Name | C-Type Lectin Domain Family 4 Member KLangerinCd Antigen Cd207 |
| Database Links | Reactome: R-HSA-1236978 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinFound In Birbeck Granules (Bgs)Which Are Organelles Consisting Of Superimposed And Zippered Membranes |
| Alternative ELISA Names | C-Type Lectin Domain Family 4 Member K ELISA kitLangerin ELISA kitCd Antigen Cd207 ELISA kitCD207 ELISA kitCLEC4K ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
