• Human CLASP2 (CLIP-associating protein 2) Sandwich ELISA Kit Ready-To-Use (STJE0014342)

Human CLASP2 (CLIP-associating protein 2) Sandwich ELISA Kit Ready-To-Use (STJE0014342)

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STJE0014342

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 11.45pg/mL
Detection Limit: 31.2-2000pg/mL
Short Description: This CLASP2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CLASP2
Gene ID: 23122
Uniprot ID: CLAP2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Brain-specific.
Post Translational Modifications Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.
Function Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Protein Name Clip-Associating Protein 2
Cytoplasmic Linker-Associated Protein 2
Protein Orbit Homolog 2
Horbit2
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-428890
Reactome: R-HSA-5663220
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Chromosome
Centromere
Kinetochore
Spindle
Golgi Apparatus
Trans-Golgi Network
Cell Membrane
Cell Projection
Ruffle Membrane
Localizes To Microtubule Plus Ends
Localizes To Centrosomes
Kinetochores And The Mitotic Spindle From Prometaphase
Subsequently Localizes To The Spindle Midzone From Anaphase And To The Midbody From Telophase
In Migrating Cells Localizes To The Plus Ends Of Microtubules Within The Cell Body And To The Entire Microtubule Lattice Within The Lamella
Localizes To The Cell Cortex And This Requires Erc1 And Phldb2
The Memo1-Rhoa-Diaph1 Signaling Pathway Controls Localization Of The Phosphorylated Form To The Cell Membrane
Alternative ELISA Names Clip-Associating Protein 2 ELISA kit
Cytoplasmic Linker-Associated Protein 2 ELISA kit
Protein Orbit Homolog 2 ELISA kit
Horbit2 ELISA kit
CLASP2 ELISA kit
KIAA0627 ELISA kit
output

Information sourced from Uniprot.org

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