| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.072ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This CES1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
CES1 |
| Gene ID: |
1066 |
| Uniprot ID: |
EST1_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed predominantly in liver with lower levels in heart and lung. Expressed in macrophages. |
| Post Translational Modifications | Contains sialic acid. Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19. |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile. |
| Protein Name | Liver Carboxylesterase 1Acyl-Coenzyme A -Cholesterol AcyltransferaseAcatBrain Carboxylesterase Hbr1Carboxylesterase 1Ce-1Hce-1Cholesteryl Ester HydrolaseCehCocaine CarboxylesteraseEgasynHmseMethylumbelliferyl-Acetate Deacetylase 1Monocyte/Macrophage Serine EsteraseRetinyl Ester HydrolaseRehSerine Esterase 1Triacylglycerol HydrolaseTgh |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-211945Reactome: R-HSA-5578768Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum LumenCytoplasmLipid DropletMoves From Cytoplasm To Lipid Droplets Upon Lipid LoadingAssociates With Lipid Droplets Independently Of Triglycerides (Tg) Content Of The Droplets And Hydrolyzes Cholesteryl Esters More Efficiently From Mixed Droplets |
| Alternative ELISA Names | Liver Carboxylesterase 1 ELISA kitAcyl-Coenzyme A -Cholesterol Acyltransferase ELISA kitAcat ELISA kitBrain Carboxylesterase Hbr1 ELISA kitCarboxylesterase 1 ELISA kitCe-1 ELISA kitHce-1 ELISA kitCholesteryl Ester Hydrolase ELISA kitCeh ELISA kitCocaine Carboxylesterase ELISA kitEgasyn ELISA kitHmse ELISA kitMethylumbelliferyl-Acetate Deacetylase 1 ELISA kitMonocyte/Macrophage Serine Esterase ELISA kitRetinyl Ester Hydrolase ELISA kitReh ELISA kitSerine Esterase 1 ELISA kitTriacylglycerol Hydrolase ELISA kitTgh ELISA kitCES1 ELISA kitCES2 ELISA kitSES1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
