• Human CD40L (Cluster Of Differentiation 40 Ligand) Sandwich ELISA Kit Ready-To-Use (STJE0014189)

Human CD40L (Cluster Of Differentiation 40 Ligand) Sandwich ELISA Kit Ready-To-Use (STJE0014189)

SKU:
STJE0014189

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.051ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CD40L Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CD40LG
Gene ID: 959
Uniprot ID: CD40L_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Specifically expressed on activated CD4+ T-lymphocytes.
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing. N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40. Not O-glycosylated.
Function Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. CD40 ligand, soluble form: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3.both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Protein Name Cd40 Ligand
Cd40-L
T-Cell Antigen Gp39
Tnf-Related Activation Protein
Trap
Tumor Necrosis Factor Ligand Superfamily Member 5
Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form
Scd40l
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-5668541
Reactome: R-HSA-5676594
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Cell Surface
Cd40 Ligand
Soluble Form: Secreted
Release Of Soluble Cd40l From Platelets Is Partially Regulated By Gp Iib/Iiia
Actin Polymerization
And A Matrix Metalloproteinases (Mmp) Inhibitor-Sensitive Pathway
Alternative ELISA Names Cd40 Ligand ELISA kit
Cd40-L ELISA kit
T-Cell Antigen Gp39 ELISA kit
Tnf-Related Activation Protein ELISA kit
Trap ELISA kit
Tumor Necrosis Factor Ligand Superfamily Member 5 ELISA kit
Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form ELISA kit
Scd40l ELISA kit
CD40LG ELISA kit
CD40L ELISA kit
TNFSF5 ELISA kit
TRAP ELISA kit
output

Information sourced from Uniprot.org

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