| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CD28-N-His & Avi protein was developed from hek293 cells and has a target region of N-His & Avi. For use in research applications. |
| Conjugation: |
Biotin |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Immobilized Human/Cynomolgus/Rhesus macaque CD28, His Tag at 0.5 Mu g/mL (100 Mu L/Well) on the plate. Dose response curve for Anti-CD28 Ab, hFc Tag with the EC50 of 17.3 ng/mL determined by ELISA. |
| Gene Symbol: |
CD28 |
| Gene ID: |
940 |
| Uniprot ID: |
CD28_HUMAN |
| Immunogen Region: |
Thr17-Pro152 |
| Immunogen: |
Biotinylated Recombinant Human CD28 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Thr17-Pro152) of Human CD28 fused with a His tag and Avi tag at the N-terminal. |
| Post Translational Modifications | CD40LG induces tyrosine phosphorylation of isoform 3. |
| Function | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. |
| Protein Name | T-Cell-Specific Surface Glycoprotein Cd28Tp44Cd Antigen Cd28 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-164939Reactome: R-HSA-2219530Reactome: R-HSA-389356Reactome: R-HSA-389357Reactome: R-HSA-389359Reactome: R-HSA-6811558 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinIsoform 3: Cell Surface |
| Alternative Protein Names | T-Cell-Specific Surface Glycoprotein Cd28 proteinTp44 proteinCd Antigen Cd28 proteinCD28 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
